Tell us about a time when you encountered a problem during an experiment and how you resolved it.

Sample answer to the question

During an experiment, I once encountered a problem when the PCR machine malfunctioned and didn't reach the desired temperature. I quickly realized that the experiment couldn't proceed without the correct temperature. To resolve the issue, I immediately notified my supervisor and consulted with the lab technician. We determined that the machine needed calibration. While waiting for the technician to calibrate it, I used the time to double-check the remaining equipment and re-read the experiment's protocols. Once the PCR machine was calibrated, I re-ran the experiment and ensured that it achieved the correct temperature. The experiment proceeded smoothly after that, and I learned the importance of regularly maintaining lab equipment.

A more solid answer

During an experiment, I encountered a problem when the PCR machine unexpectedly stopped working. I immediately halted the experiment to prevent any data loss. After checking the machine's settings and troubleshooting, I couldn't identify the issue, so I sought assistance from my supervisor. Together, we reviewed the PCR machine's maintenance logs and realized it was due for cleaning. With guidance from my supervisor, I conducted a thorough cleaning of the machine according to the manufacturer's instructions. Once cleaned and reassembled, I ran a diagnostic test to ensure it was functioning properly. With the PCR machine back in optimal condition, I resumed the experiment and successfully obtained the desired results. This experience taught me the importance of regular equipment maintenance and the value of seeking guidance when faced with unfamiliar problems.

Why this is a more solid answer:

The solid answer provides a more detailed account of encountering a problem during an experiment and outlines the steps taken to resolve it. It demonstrates problem-solving skills, attention to detail, and the ability to work independently. However, it could further emphasize the candidate's communication skills and how they effectively communicated with their supervisor.

An exceptional answer

During a crucial experiment, I encountered a problem when the gel electrophoresis results didn't match the expected outcome. Recognizing the importance of accurate results, I took immediate action. First, I carefully reviewed the experiment's protocols and confirmed that I had followed every step correctly. Next, I consulted with my colleagues to gather their input and insights. Through collaborative brainstorming, we speculated that the problem could be due to an issue with the gel itself. To test this hypothesis, I proactively prepared a fresh batch of gel, ensuring its quality and accuracy. I reran the experiment using the new gel, and the results aligned with the expected outcome, providing the clarity we needed. This experience not only showcased my problem-solving abilities, but it also highlighted my collaborative and proactive approach to finding solutions.

Why this is an exceptional answer:

The exceptional answer goes beyond a basic problem-solving approach and highlights the candidate's ability to think critically and collaborate effectively. It demonstrates their attention to detail, initiative, and proactive nature. The candidate also emphasizes their commitment to maintaining the integrity of the experiment and achieving accurate results. However, the answer could still provide more insights into how the candidate communicated their findings and shared their progress with their team.

How to prepare for this question

Familiarize yourself with common issues that can arise during experiments, such as equipment malfunctions and discrepancies in results.
Develop problem-solving strategies for troubleshooting and resolving experiment-related problems.
Practice effectively communicating problems and seeking assistance from supervisors or colleagues.
Highlight instances where you took proactive steps to ensure accurate results and maintain the integrity of experiments.

What interviewers are evaluating

Problem-solving skills
Attention to detail
Ability to work independently
Communication skills